Age specific mortality and immunity patterns of SARS CoV2
In this study researchers explored the case fatality ratio for COVID-19 among all age ranges. They found that mortality is lowest among kids 5-9 years old and that there’s a log-linear increase by age among individuals over 30. They conclude that age and risks from living in a nursing home explains some (but not all) of the differences between countries when it comes to infection-fatality ratios.
“Among the 45 countries included in our analysis, we estimate approximately 5% of these populations had been infected by the 1st of September 2020, with much higher transmission likely to have occurred in a number of Latin American countries. This simple modelling framework can help countries assess the progression of the pandemic and can be applied wherever reliable age-specific death data exists.”
MMWR: Transmission of COVID-19 in Households
A new MMWR from the CDC describes COVID-19 transmissions in households. The report found that there was a 53% secondary infection rate in households. The results reinforce the idea that folks should self-isolate and wear masks in shared household spaces.
SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19
In a phase 2 trial, outpatients with Covid-19 who received a single infusion of a 2800-mg dose of the neutralizing antibody had a greater reduction in viral load compared to people who got the placebo. Hospitalization was less frequent among antibody-treated patients too (1.6% vs. 6.3%). Here’s the article.
New and Updated MMWR: Characteristics of Symptomatic Women and Infants Following COVID-19 Infection in Pregnancy
In a new MMWR, authors describe pregnancy outcomes among women with COVID-19 infection. Through the Surveillance for Emerging Threats to Mothers and Babies Network, 16 jurisdictions collected information on pregnancy and infant outcomes among 5,252 women with COVID-19 infection reported during March 29–Oct. 14, 2020.
Both preterm birth and adverse infant outcomes were observed at higher rates among women with COVID-19 infection. Additionally, CDC provided an update on characteristics of symptomatic women of reproductive age with COVID-19 infection.
