NATURE: NATURALLY ENHANCED NEUTRALIZING BREADTH AGAINST SARS-COV-2 ONE YEAR AFTER INFECTION

This study found that immunity in previously infected but unvaccinated persons is is long lasting. Previously infected persons that get vaccinated post infection produce additional antibodies and memory B cells that increase immunity and are protective against circulating SARS-CoV-2 variants.

“In the absence of vaccination antibody reactivity to the receptor binding domain (RBD) of SARS-CoV-2, neutralizing activity and the number of RBD-specific memory B cells remain relatively stable from 6 to 12 months.

Vaccination increases all components of the humoral response, and as expected, results in serum neutralizing activities against variants of concern that are comparable to or greater than neutralizing activity against the original Wuhan Hu-1 achieved by vaccination of naive individuals.”

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