Yesterday brought an unexpected detection of H5N1 ‘avian’ influenza RNA in wastewater from three cities in Maricopa County—Phoenix, Tempe, and Surprise. H5N1 mostly affects wild birds, domestic poultry, and a handful of mammal species (including mild infections among human agricultural workers. But, with no human-to-human transmission and urban Maricopa County not being super agricultural, its presence in wastewater raises intriguing questions about the source. Let’s explore why and the implications.
What is H5N1?
H5N1 (aka avian influenza) is a strain of avian influenza virus that has caused severe outbreaks among wild birds and domestic fowl. Infections in mammals have been rare and mostly mild. Some agricultural workers with close contact with infected birds or cattle have been infected, but with mild symptoms and with no documented human-to-human transmission.
The Wastewater Detections
The ADHS State Laboratory confirmed the presence of H5 RNA in wastewater samples collected from Phoenix, Tempe, and Surprise. The finding was surprising because these cities are not known for large-scale poultry farming (where such a virus might be expected in domestic wastewater).
Also, all three cities say that their stormwater systems (which collect rainwater and runoff) are completely separate from their wastewater systems (which handle sewage). This separation means that the virus’s presence can’t be attributed to wild birds contaminating street drains and then getting into domestic wastewater.
Where’s it Coming From?
So, where is the H5 RNA coming from? After consulting with public health experts, the most plausible explanation points to backyard chicken flocks. Backyard poultry keeping has grown in popularity, and infected chickens could easily introduce the virus into wastewater through improper disposal of chicken tissue via household sinks.
Note: ARS 11-820.04 prohibits counties from adopting laws or regulations prohibiting residents from keeping up to six fowl in their backyards.
While it’s theoretically possible the source of the detections of H5 in wastewater are human infections, it seems like a longshot since no human-to-human transmission of H5N1 has been documented.
What’s Next?
As part of normal annual influenza surveillance, randomly selected specimens from human influenza infections (which is increasing quickly right now) are routinely sequenced – and if some of them are H5 (rather than the ubiquitous H1N1 and H3N2 strains) we should know shortly.
Note: The ADHS State Lab (which confirmed these detections) is finishing its validation protocol for the H5N1 wastewater validation test, with certification by the CDC expected soon. ADHS’ H5N1 assay for human infections IS validated.
Should We Be Concerned?
For now, there’s no need for alarm. Human cases of H5N1 remain rare, mild and there’s is no evidence of human-to-human transmission. However, these detections underscore the importance of vigilance, proper biosecurity measures for backyard flocks, and ongoing surveillance of both human and animal health.
We’ll continue to be on top of local and national developments – but for now there’s nothing to freak about.