There’s encouraging news about the overdose crisis in the United States. Drug overdose deaths fell for the third year in a row in 2025.
But Arizona is heading in the opposite direction.
In a new AzPHA special report by Allan Williams, PhD, MPH, we took a closer look at the numbers. Nationwide, estimated overdose deaths dropped by nearly 14% last year, falling from about 81,300 deaths in 2024 to just under 70,000 in 2025. That’s the lowest national total since 2018.
Arizona’s numbers are much more troubling. Estimated overdose deaths increased by 18%, rising from 2,531 in 2024 to 2,988 in 2025.
The increases weren’t limited to one type of drug. Deaths involving synthetic opioids — mostly fentanyl — increased by nearly 33%. Deaths involving methamphetamine and other stimulants rose by more than 15%. Cocaine-related deaths jumped by almost 70%.
The national decline shows that progress is possible. Wider access to naloxone, fentanyl test strips, treatment programs and other harm-reduction tools appears to be saving lives. Opioid-settlement funding may also be helping communities expand prevention and treatment services.
Arizona needs to make naloxone and fentanyl test strips easier to get. We need faster access to proven treatment for substance-use disorders. We also need to make sure opioid-settlement dollars are spent on programs that can show measurable results.
Nearly 3,000 Arizonans died from drug overdoses last year. Behind every number is a family, a workplace and a community.
Read the full AzPHA special report for the detailed numbers, charts and policy recommendations.








