From Lab Bench to Treatment: Why NIH Funding Matters for New Cancer Treatments

When people hear about breakthrough cancer treatment in a statement from a drug company it might seem can sound like they suddenly invented something amazing. That’s usually not how it works.

Most new treatments start with basic research funded by the NIH and the National Cancer Institute. That early funding helps scientists learn how diseases work and test new ideas long before any company is ready to spend big money.

mRNA technology is a good example. The science behind it was built over many years with public support, long before it became a household term.

Now look at pancreatic cancer. A personalized mRNA treatment called autogene cevumeran is being evaluated after surgery in patients with pancreatic cancer. The idea is to train the immune system to spot and attack any cancer cells left behind.

Early (Phase 1) results were promising enough that the work moved into a larger global Phase 2 trial sponsored by Genentech in collaboration with BioNTech (which is underway with hundreds of patients right now).

That’s the pattern we see again and again: public funding helps build the platform; private industry funds the bigger trials needed to bring treatments to market.

And here’s the twist. Kennedy is openly hostile to mRNA technology, and he ended federal support for mRNA-related projects.

The good news is that the earlier basic research found this technology has potential applications for a host of cancer treatments, including for post-surgery pancreatic cancer.

The results found from decades of public investment that already helped launch mRNA into cancer research means that Kennedy won’t be able to single-handedly kill these new therapies. Even if new mRNA cancer treatments make it through their clinical trials and Kennedy directs the FDA to not license the therapy because of his confirmation bias mentality – he will be gone in 2.5 years.

And one more thing…  if the pancreatic cancer trials pan out, a lot of MAHA people who spent years attacking mRNA may suddenly decide they’re very much in favor of it (or pretend they were never against the technology).

Note: In an ominous twist this week, the president dismissed all members of the National Science Board, the independent body that sets policy for the National Science Foundation and advises Congress and the president on science and education.

2024 ballot propositions

AHCCCS 101 Series: What We Covered

Over the last month, we took a deep dive into Arizona’s Medicaid program… the Arizona Health Care Cost Containment System (AHCCCS). It’s a $20+ billion system that covers more than 2 million Arizonans and runs very differently than most state Medicaid programs.

If you missed any part of the series, here’s the full rundown—and why it matters for public health policy right now.

Part 1: Why Arizona Built Medicaid Differently

https://azpha.org/2026/04/07/ahcccs-101-part-1-of-4-ahcccs-origin-story-why-arizona-built-medicaid-different/

Arizona was the last state to adopt Medicaid—but when it did in 1982, it skipped the traditional fee-for-service model and went straight to managed care. That decision still defines AHCCCS today. Instead of paying providers directly for each service, the state pays health plans a set amount per member to manage care.

That structure has made AHCCCS one of the most cost-controlled Medicaid programs in the country—but it also means everything hinges on contracts and oversight.

Part 2: Who Really Makes the Decisions

https://azpha.org/2026/04/14/ahcccs-101-part-2-waivers-state-plan-amendments-and-who-decides/

AHCCCS doesn’t work in a vacuum. Federal law sets the guardrails, but states have flexibility through tools like 1115 waivers and State Plan Amendments.

This part unpacked a key reality: innovation (like housing supports or community-based services) only happens when AHCCCS designs it and CMS approves it. That shared authority shapes what’s possible—and how fast change happens.

Part 3: Contracts, Accountability, and Performance

https://azpha.org/2026/04/21/ahcccs-101-part-3-contract-management-accountability/

Because AHCCCS is fully managed care, contracts are the backbone of the system. Health plans handle delivering care, meeting quality benchmarks, and managing costs.

We walked through how AHCCCS uses tools like performance metrics, financial penalties, and quality standards (HEDIS, ACOM) to hold plans accountable.

Bottom line: If the contracts are strong and enforced, the system works. If not, outcomes suffer.

Part 4: From Coverage to Care – The Member Experience

https://azpha.org/2026/04/29/ahcccs-101-part-4-from-coverage-to-care-the-member-experience/

Coverage doesn’t automatically mean care. This final piece focused on what it’s actually like to navigate AHCCCS.

From plan choice (or auto-assignment) to provider networks to the well-known frustrations with Health-e-Arizona Plus, the member experience can be uneven—especially for people with complex needs like serious mental illness or long-term care.

The Bottom Line

AHCCCS is the healthcare system for low-income residents and people with disabilities covering everything from primary care to behavioral health services to home and community-based services for folks with developmental and intellectual disabilities.

The managed care model is both the program’s strength and its risk. Federal-state dynamics shape what Arizona can and can’t do. Contracts and oversight determine whether the system delivers results. And the member experience is where policy either succeeds or fails.

Note:  AHCCCS has a new Online Provider Directory that lets members get daily‑updated data and flexible search options by name, provider type, specialty, or location in the AHCCCS networks.

By This Time Next Week It’ll be a Crime to Provide Humanitarian Aid in Phoenix City Parks

By this time next week, handing someone a sandwich, a pair of socks, or basic wound care in a Phoenix park will be a crime (a Class 1 misdemeanor – the worst kind).

Phoenix Imposes Criminal Penalties for Providing ‘Street Medicine’ in Parks without the Parks Director’s Permission

The hearing will be on June 6 at 2:30pm. It will likely be performative on the part of the Council.

The brainchildren for proposing this cruel ordinance are recently promoted former Parks Department Manager (and now Deputy City Manager) Cynthia Aguilar and City Manager Ed Zuercher (who makes $415,542 per year).

The proposed ordinance would make it illegal to provide medical care or distribute food in city parks without a permit. On paper, it creates a narrow pathway for very limited opportunities to provide very limited aid if an organization applies for and gets a permit to do so.

But, even if the Parks Department lets them do it (they won’t) it’s limited to just 2 events per month total, very limited time windows, and restrictions like making them set up a tent in a parking lot (which the city staff probably won’t let them do anyway).

In practice, folks who’ve worked with the Parks Department know those permits won’t be issued in any meaningful way.

Organizations like Phoenix Street Medicine, Circle the City, and others have been doing quiet, essential work for years…  things like basic wound care, hygiene supplies, food, connection to services will need to stop or face jail time and fines (6 months in jail and a fine of $2,500 plus court surcharges).

Even with a permit (that won’t be issued), the proposal completely bans syringe services and any care involving needles. Naloxone for overdose reversal appears to remain allowed but only in emergencies.

There’s also a requirement that any approved services be provided from a “shelter” placed on pavement. Again, something the city is unlikely to approve.

I’ve now heard from multiple people who’ve met with Mayor Kate Gallego that, while she listened politely, they all left thinking the decision is a locked in ‘yes’.

And if you’ve watched the Phoenix City Council over time, you know the pattern: proposals from City Manager and Parks leadership tend to get rubber stamped with minimal resistance once they’re on the Council agenda.

We can expect one “no” vote (Councilmember Anna Hernandez). There will be lots of public comment (including ours) that will be ignored, and the Council will pass this. Just watch.

But that doesn’t mean our opposition is meaningless. Even when the outcome is locked in, the public record matters. Silence gets interpreted as consent… and we will be putting in comments to make it clear we object.

If you’re inclined, send a comment or sign up to speak:

https://www.phoenix.gov/administration/departments/cityclerk/programs-services/city-council-meetings.html

You can also review the ordinance itself:

https://www.phoenix.gov/administration/departments/parks/about-us/medical-treatment-and-food-distribution-in-parks.html#new-proposed-ordinance

And here’s more reporting for context:

https://www.phoenixnewtimes.com/news/phoenix-may-ban-handing-out-drug-testing-kits-city-parks-40629434/

When you make basic humanitarian aid a crime, you don’t solve homelessness, you simply kick them in the teeth.

State House of Representative Passes a Fake Budget: Senate to Approve it this Week (Followed by a Veto)

Then the Real Negotiations Begin

Last week House and Senate Republicans rolled out and had hearings on mirror-image budget proposals. The House version passed last week. The identical Senate version will pass this week – followed by a prompt veto.

Then then the real budget negotiations will begin.

This initial budget emphasizes tax cuts, spending reductions (especially agency budget cuts). Dems highlight potential impacts on healthcare coverage, food aid, and core services.

Normally I’d include a link to the budget the House passed here – but I’ll refrain as it is DOA on the 9th floor.

For now, nearly all policy bills (including those related to public health and healthcare) are in suspended animation.

That includes the bills we’ve been weighing in on this session. For a refresher on where things stood heading into this phase just click on our blog post from earlier in April (not much has changed since then):

https://azpha.org/2026/03/29/legislative-session-summary-committee-deadlines-hit-floor-action-accelerates-and-budget-negotiations-start/

In the meantime, a budget compromise will eventually appear, and they’ll finish the session in a blaze of late-night sessions, probably in May sometime.

Note: It’s during those late-night sessions that the Republicans will decide which of the many ballot propositions they will place on the November ballot. I’m certain there will be at least a few that relate directly to public health and healthcare (for the bad). There are also a couple of voter initiatives that are collecting signatures that will affect public health – or public health adjacent stuff like voting rights.

AZ Grant Opportunities – Compiled by Vitalyst Health Foundation

Due April 15th: Spark Good Local Grants

Due April 15th: O’Reilly Auto Parts Foundation (Social Issues)

Due April 16th: Medical Assistance Grants (Maricopa County; Hearing, Vision, Substance Use Disorder, and Heart/Lung)

Due April 17th: Jewish Community Foundation (Prescott)

Due April 17th: Housing Solutions Notice of Funding (ADOH)

Due April 20th: Children’s Mental Health Initiative

Due April 22nd: Value-Added Producer Grants (Federal)

Due April 24th: Custom Web Application Grant

Due April 24th: Cyber Preparedness Grant

NEW Due April 27th: Adult Treatment Court Program (Federal Funding)

NEW Due April 27th: Veterans Treatment Court Program (Federal Funding)

NEW Due April 30th: Mary Kay Ash Foundation Domestic Violence Shelter Grants

Due April 30th: Vilcek Foundation (Arts and Science)

Due April 30th: The James B. & Lois R. Archer Charitable Foundation

NEW Due May 1st: Knowledge Sharing & Awareness Raising Grants (Age Equity, Caregiving, Economic Security, Housing, and Social Connection)

Due May 1st: Surprise Community Outreach Program (Surprise; Direct Services)

Due May 1st: Purpose Prize® from AARP (“live as they age”)

Due May 1st: Sparkplug Foundation (Education, Community Organizing, and Music)

NEW Due May 15th: Owner Occupied Housing Rehabilitation

NEW Due May 15th: National Housing Innovation Grant Competition

NEW Due May 20th: Disability Inclusion Fund

NEW Due May 20th: AmeriCorps State and National Native Nations Grants

Due May 25th: Information Resource Grants to Reduce Health Disparities and Promote Health for All (Federal)

NEW Due May 29th: Tribal Projects (State; Tribal; Housing)

NEW Due May 31st: Fast Pitch Competition (Women Founders Network)

NEW June 1st: Love Your Block

NEW Due June 11th: Funding for Strategic Collaboration in the Impact Investing Sector

NEW Due June 12th: Wayne F. Placek Grants (LGBTQIA+)

NEW Due June 16th: AI-Ready America

Due July 15th (opens May 1st): 
Spark Good Local Grants

Due July 24th: Custom Web Application Grant

Due July 24th: Cyber Preparedness Grant

Due October 23rd: Custom Web Application Grant

Due October 23rd: Cyber Preparedness Grant

Ongoing: HEARST Foundation (Health)

Ongoing: Amateur Radio (AR) and Digital Communications (DC) Funding

Ongoing: Arizona Housing Fund 

Ongoing: Arizona Together for Impact Fund

 

https://azpha.org/wp-content/uploads/2026/05/RHC-Presentation-2024-Ballot-Measures.pptx

AHCCCS 101, Part 4: From Coverage to Care – The Member Experience

In Parts 1 through 3, we walked through how AHCCCS was founded, how it was built, how Arizona gets permission to run it and how the system is supposed to work.

AHCCCS 101 (Part 1): AHCCCS’ Origin Story – Why Arizona Built Medicaid Different

AHCCCS 101 (Part 2): Waivers, State Plan Amendments and Who Decides

AHCCCS 101 (Part 3): Contract Management & Accountability

This final part (Part 4) looks at what it’s like from a member point of view. 

A member’s experience usually starts with an application through Health-e-Arizona Plus (HEAplus), the state’s online portal.

In theory, it’s a single front door for Medicaid, nutrition assistance, and other benefits. In practice, it can be hard to use.

Many users describe HEAplus as clunky and outdated (it uses a really old coding language). The screens aren’t always clear. Uploading documents can be confusing. People sometimes get stuck in loops where the system keeps asking for the same information.

Another common problem is identity verification. Some users say they can’t get past that step at all. Part of that process involves federal systems and contractors like Experian working with Centers for Medicare & Medicaid Services. But for the person trying to apply, that detail doesn’t really matter. If they can’t verify their identity, they can’t finish the application and they have a much harder time getting coverage.

Once someone is approved, they don’t just “have AHCCCS.” They’re enrolled in a health plan. If they don’t pick one, they’re auto-assigned to one.

AHCCCS uses a formula to spread new members across plans. They say their goal is to balance enrollment and keep access stable. Plans sometimes argue about whether the formula is fair, and the auto assignment of a plan can affect which doctors a member can see.

After enrollment, the member’s experience depends a lot on their health plan.

Each plan (MCO or Managed Care Organization) has its own network of doctors and providers. On paper, plans have to meet network sufficiency standards, meaning there should be enough providers. In real life, it can still be hard to find a doctor who is taking new patients or to get a quick appointment with a specialist, especially in rural places.

When a member needs care, some services are simple to get. Others need prior authorization, which means the plan has to approve the service first. This can help control costs, but it can also slow things down or lead to denials.

For people with more complex needs (like those with disabilities or serious mental illness) the system has higher expectations. Their care often involves many providers and services at the same time. AHCCCS requires plans to coordinate that care but doing it well every time is hard.

As we talked about in Part 3 – it’s not the requirement for an adequate network and care coordination – what really matters is compliance with the requirement. 

If something goes wrong like a denial or a delay, members can file a grievance or an appeal. These tools are important, but they can be hard to use. Many people don’t file them because the process is confusing or takes too much time.

Another challenge is renewal (“redetermination”). Members have to prove from time to time that they still qualify. If they miss a notice or don’t send in paperwork on time, they can lose coverage even if they’re still eligible. 

One common problem is that a letter is stamp mailed to the member asking them to verify their income and other resources (with 10 days to respond). If they moved apartments and didn’t update their new address, they won’t get the letter, so they don’t respond, and can lose their coverage without knowing it until they try to make a doctor’s appointment or go to an ED – so updating contact information is of prime importance for members to do.

All of this stuff connects back to how the system is designed.

Remember from the earlier parts in this series…. AHCCCS pays health plans a fixed amount per member each month. That creates pressure to manage costs. Sometimes that leads to better care and coordination. Other times, it shows up as tighter networks, more approvals, or delays that members feel.

AHCCCS provides essential coverage for millions of Arizonans. But as anybody with a health insurance plan of any kind knows (not just Medicaid members), coverage isn’t the same as access and access isn’t the same as treatment and care coordination.

I hope you found this AHCCCS 101 series informative. 

In Part 1, we covered why Arizona built AHCCCS using managed care. In Part 2, we explained how waivers and State Plan Amendments let the state run and change the program.
In Part 3, we showed how AHCCCS manages its contracts and holds health plans accountable.

This final piece shows the member experience. 

Note: AHCCCS is working on a new Community Engagement Portal that’s supposed to improve the AHCCCS member experience in advance of the looming work and community engagement requirements for the expansion population. They’re having some virtual sessions about their system goals this week for target populations: 

Thursday, April 30 | 1:00 – 2:00 PM

[AHCCCS H.R. 1 Community Engagement Stakeholder – Option 1 (CBOs / Member Assistors)]
Friday, May 1 | 9:00 – 10:00 AM

[AHCCCS H.R. 1 Community Engagement Stakeholder – Option 2 (CBOs / Member Assistors)]

CDC Buries MMWR Documenting the Effectiveness of the COVID Vaccine  Next: An Alpha Test for Incoming CDC Director Schwartz

Acting CDC director Bhattacharya killed a ready-to-publish Morbidity and Mortality Weekly Report (MMWR) this week which would have shown impressive effectiveness of COVID vaccines in preventing hospitalizations over the last couple years.

The analysis had already cleared evidence and technical review by career staff at the CDC. Then it got 86’d by Kennedy/Bhattacharya.

It isn’t surprising that Bhattacharya buried it. He knows what he did was wrong but doesn’t care because he’s loyal to Kennedy rather than evidence. 

I’ll be looking to see whether incoming CDC Director Erica Schwartz and her Deputy Director/CMO Jennifer Shuford publish the MMWR when they’re at their posts in a few weeks. It’ll be a good Alpha Test to forecast whether CDC’s reputation will improve or not under their leadership.

On paper, they are good picks. There’s a credible case that CDC could start turning the corner with them in charge. I’m cautiously optimistic.

But my optimism isn’t what matters. Schwartz and Shuford’s behavior is what will matter.

If Schwartz and Shuford take their posts and this MMWR stays buried or if a watered-down political document ends up being published, we’ll know that my optimism was unfounded (again).

If, on the other hand, if they publish the MMWR without watering it down it might be a sign that we can be optimistic about their future decisions.

This is a classic public health leadership test: Are you more interested in doing your job or keeping your job?

We’re about to find out which way it goes for Schwartz and Shuford.

ASTHO Statement on Appointment of Texas Commissioner Jennifer Shuford, MD, MPH, as CDC Deputy Director | ASTHO

Spot Bad Arguments Before They Spread

Dr. Greg Loeben joined us today for our Conversations & Coffee event and took on a problem every public health professional runs into: misleading arguments that sound convincing but fall apart under scrutiny.

His core points were that bad reasoning spreads faster than good evidence. If you can recognize the pattern, you can respond more effectively in real time.

Greg walked through seven common logical fallacies that show up all the time in public health debates:

  • Appeal to authority – leaning on a person’s status instead of evidence
  • Ad hominem – attacking the person rather than the argument
  • Appeal to nature – assuming “natural” means safe or better
  • False dilemma – presenting only two choices when more exist
  • Straw man – distorting someone’s position to make it easier to attack
  • Slippery slope – claiming one step will trigger extreme outcomes
  • Hasty generalization – drawing broad conclusions from limited data

He made a useful distinction: cognitive biases are how our brains tend to process information, while fallacies are errors in the structure of an argument. Social media makes both worse by rewarding attention, not accuracy.

The practical takeaway wasn’t “win the argument.” It was to recognize the pattern and respond strategically. Sometimes that means asking a clarifying question (“Are those really the only two options?”). Sometimes it means pointing out the mismatch (“That’s not what I said”). And sometimes—especially with family—it means disengaging.

Bottom line: You don’t need to memorize philosophy terms. You need pattern recognition. Once you see the structure of a bad argument, it’s a lot harder to be pulled in by it—and a lot easier to steer the conversation back to evidence.

I really encourage you to invest an hour in the webinar! I mean it. I learned more in that 50 minutes Friday than I have in a long time.

View the Coffee & Conversations Webinar 

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