Long COVID: Persistent Symptoms and Functional Impacts 5 Years After Infection

As the COVID-19 pandemic marks its fifth year, many people who’ve recovered from the virus continue to suffer from lingering symptoms known as “Long COVID”. This condition affects a significant portion of people who had moderate or severe COVID-19 infections, with people reporting symptoms persisting for months or even years after the initial infection.

Main Symptoms of Long COVID

The symptoms of long COVID vary widely and can affect multiple organ systems. Among the most common and persistent are neurological symptoms, including brain fog, difficulty concentrating, and memory problems, which can severely impair cognitive function and hinder work and daily activities. These cognitive issues are often described as “mental fatigue” or “cloudy thinking” and are a central complaint among long COVID patients.

Fatigue is another symptom, often reported as severe & debilitating. This fatigue is not simply tiredness but a deep, persistent exhaustion that does not improve with rest. Patients often struggle with even basic tasks due to this overwhelming tiredness.

In addition to fatigue, individuals with long COVID often experience musculoskeletal pain, including joint pain and muscle aches. This, coupled with chronic headaches and dizziness, can contribute to a significant decline in quality of life. Some patients also report shortness of breath and ongoing respiratory issues, even long after the acute phase of infection has passed.

Functional Changes

Sometimes Long COVID can cause functional changes in individuals’ ability to carry out everyday tasks. Many have difficulty returning to work or normal activities due to the persistent physical and cognitive symptoms. Exhaustion and pain often require modifications to their daily routines, and some individuals may need to reduce working hours or rely on help for tasks they once performed independently.

Mental Health Impact

The ongoing nature of long COVID can contribute to mental health challenges. Anxiety and depression have been reported by long COVID patients, possibly due to the frustration of living with an uncertain and often misunderstood condition. The burden of prolonged illness, combined with the uncertainty about recovery, worsens emotional and psychological stress.

New Report Reviews Evidence on Long COVID Diagnosis, Risk, Symptoms, and Functional Impact for Patients | National Academies

Long COVID: major findings, mechanisms and recommendations | Nature Reviews Microbiology

Long COVID | NHLBI, NIH

How common is long COVID? Why studies give different answers

Treatment

Physical rehabilitation like exercise and activity management helps some patients alleviate fatigue and improve physical function. Some clinicians are using medications targeting specific symptoms, such as low-dose naltrexone for pain and inflammation, are under investigation for their potential benefits.

Management of long COVID also includes psychological therapies like cognitive behavioral therapy, ‘acceptance and commitment therapy’, group therapy, and peer support.

Legislative Update: Week of March 17

This week was dominated by floor votes (called 3rd Read). Bills that successfully get approved on the floor vote then move over to the other chamber.

Committees are also back in full swing. The Senate and House Health and Human Services Committees are meeting this week on several bills. Rather than discuss them here (this is already a long update) I’ll just link you to our weekly committee worksheet.

Here’s a list of the public health related bills that have advanced out of their chamber over the last couple of weeks:

Senate

SB1019 photo enforcement; traffic (AzPHA opposes)

SB1071 SNAP TANF verification (AzPHA Opposed)

SB1108 international medical licenses; provisional licensing (no Position)

SB1612 RFP document retention; AHCCCS (No Position)

SB1347 – comprehensive dental; ahcccs (AzPHA Supports)

SB1604 licensed secure health facility; defendants (AzPHA Supports)

SB1623 – no vote yet -GME appropriations (AzPHA Supports)

House

HB2001 behavioral health temporary licenses (AzPHA Supports)

HB2012 emergency use products; employers (AzPHA Opposed)

HB2130 claims; prior authorization (AzPHA Supports)

HB2058 immunization proof; higher education (AzPHA Opposed)

HB2063 parental notification; school immunizations (AzPHA Opposes)

HB2125 insurance coverage; hearing aids (AzPHA Supports)

HB2126 medical records; parental choice (AzPHA Opposes)

HB2145 registered sanitarians; qualifications (AzPHA Supports)

HB2164 school lunches; ultra processed food (AzPHA Supports)

HB2165 SNAP; prohibited purchases (AzPHA No Position)

HB2175 claims; prior auth; company conduct (AzPHA Supports)

HB2176 training; investigations; complaints (AzPHA Neutral)

HB2257 DCS, vaccination; child placement (AzPHA No Position)

HB2291 opioids, red cap packaging (AzPHA Supports)

HB2449 AHCCCS presumptive eligibility (AzPHA Opposed)

HB2894 Silver alert criteria (AzPHA Supports)

FDA Bypasses Vaccines & Related Biological Products Advisory Committee: Establishes this Fall’s Influenza Vaccine Formula w/o VRBPAC Technical Review

Each March the US decides what the formulation should be for the next season’s influenza vaccine. For decades the process has been to have experts from the FDA’s Vaccines and Related Biological Products Advisory Committee (VRBPAC) analyze global surveillance in the northern and southern hemispheres and make a formula recommendation to the FDA Commissioner – with the goal of having a vaccine targeting the most likely strains that’ll be the most likely to circulate in the northern hemisphere the following fall.

Not this year. RFK Jr used his authority as HHS Secretary to cancel the March 13 VRBPAC meeting and told his FDA Commissioner to decide on their own what the 2025-2026 influenza vaccine formula should be – without expert review from VRBPAC.

Ironically, Acting FDA Commissioner Dr. Sara Brenner decided to just go with what the WHO is recommending – despite the president’s intent to withdraw from the WHO, stop paying dues… and his disparaging comments about the organization.

This fall’s formula will be trivalent, having two influenza A subtype viruses (H1N1 and H3N2) and one influenza B virus:

  • Influenza A(H1N1)pdm09-like virus: an A/Victoria/4897/2022 (H1N1)pdm09-like virus.
  • Influenza A(H3N2)-like virus: an A/Croatia/10136RV/2023 (H3N2)-like virus.
  • Influenza B (Victoria lineage)-like virus: a B/Austria/1359417/2021 (B/Victoria lineage)-like virus.

Federal Budget News: No Government Shutdown

The U.S. House of Representatives and Senate approved a ‘continuing resolution’ this week – approving the “Full Year Continuing Appropriations and Extensions Act, 2025”, to fund the federal government at current levels through the fiscal year ending Sept. 30, 2025. Here’s the text of the legislation and a section-by-section summary.

What’s still unclear is whether the agencies funded by the CR will actually follow through and actually do what the CR says they’re supposed to do with the money – and that’s the crux of the drama in congress and elsewhere.

Without firm stipulations it’s likely that the DOGE Bros and agency heads will simply not extend the funds through contracts.

In addition to extending federal funding through Sept. 30, 2025, the CR includes the following provisions relevant to state and territorial public health:

  • Extends funding for the following programs through Sept. 30, 2025:

o Community Health Centers

o Special Diabetes Program

o Teaching Health Centers that run GME

o National Disaster Medical System

o Sexual Risk Avoidance Education Program

o Personal Responsibility Education

o Family-to-Family Health Information Centers

  • Extends the authorization of the following programs through Sept. 30, 2025:

o Public Health Emergency Fund

o Biomedical Advanced Research and Development Authority

o BioShield Special Reserve Fund

o Public Health Emergency Medical Countermeasures Enterprise

o National Advisory Committee on Children and Disasters

o National Advisory Committee on Seniors and Disasters

o National Disaster Medical System

o Authority for states and tribes to request temporary reassignment for federally funded persons

Join Us at Our 2025 Conference for a Discussion of AI-Driven Advancements in Public Health Practice & More

The Arizona Public Health Association’s 2025 Annual Conference is just around the corner (April 3), and this is your chance to register for an event that promises to explore groundbreaking innovations in public health.

This year’s theme, “Using AI to Enhance Public Health Practice, Data, Informatics, and the Public Health Workforce” focuses on how artificial intelligence is transforming the field of public health.

View Our Final Agenda!

From data-driven decision-making to workforce development, this conference offers valuable opportunities for professionals, students, and organizations to learn from leading experts and take part in forward-thinking discussions.

Modernizing Public Health Practice:
Building an Innovative Infrastructure for the Public Health of the Future

Whether you’re looking to enhance your skills, explore new AI-driven technologies, or network with fellow professionals, the AZPHA 2025 Conference is an essential event for public health practitioners. Don’t miss out—register now to secure your spot and take advantage of early bird rates!

Conference Agenda

Keynote
  • Opening Keynote: Improving Perinatal Public Health: An Opportunity for Healthcare and Public Health to Collaborate
Breakout Sessions

Using AI to Enhance Public Health Practice

  • Leveraging AI to Standardize Housing Interventions
  • Merging Minds and Machines | Re-envisioning Public Health Innovation
  • Leveraging AI for Smarter Public Health Decision-Making: Balancing Innovation with Cultural Responsiveness
  • The AI Co-Worker You Never Knew You Needed

Data Infrastructure and Informatics

  • Enhancing Depression Care for Pregnant and Postpartum Women Through Data Visualization
  • Integrating Data to Action: Enhancing Overdose Surveillance and Response in Pima County
  • Substance Use Data to Action: Development of the City of Phoenix Opioid Overdose Alert System Methodology and Program Framework
  • Data as a Driver of Action: Leveraging Wastewater Monitoring for H5 Detection and Response
  • The ADHS 2024 State Health Assessment

Public Health Workforce

  • Public Health Inclusion & Belonging and Employee-Driven Approach
  • Bridging the Gap: Cultivating Public Health Leaders Through Workforce Innovation and Experiential Learning
  • Fostering Connection and Quality: Improving Behavioral Health Care Through Collaboration
  • Tribal Healthcare Workforce Development: A Collaborative Approach
  • Building a Sustainable Mental Healthcare Workforce in Arizona
  • Strengthening the Public Health Workforce by Reimaging Graduate Education
Panel Discussion
  • “Innovative Methods and Techniques in Public Health Implementation Science”

Don’t miss this opportunity to be part of an exciting and forward-thinking conference. Register today and join us in exploring how AI is reshaping the future of public health!

Special Discounts:

  • Student Discounts: Affordable rates for AZPHA student members
  • Group Discounts: Organizations registering 10 or more people can access special pricing.
  • Member Discounts: AZPHA members receive exclusive discounts
  • Free Membership: General registration includes a complimentary one-year membership with AZPHA, giving you access to additional resources and networking opportunities.
For full registration details, fees, and sponsorship opportunities, visit our registration page
View Our Final Agenda!
Register
Sponsorship Opportunities (Deadline March 18)

CDC Suspends Pregnancy Risk Assessment Monitoring System (PRAMS) Data Collection

From AzPHA Member Bre Thomas at Affirm

The CDC suspended data collection through the Pregnancy Risk Assessment Monitoring System (PRAMS) last week. PRAMS is a federal population-based surveillance system “designed to identify groups of women and infants at high risk for health problems, to monitor changes in health status, and to measure progress towards goals in improving the health of mothers and infants.”

Developed in the 1980s as part of a concerted effort to better understand why Black and Native American/Alaskan Native mothers and infants consistently experienced worse health outcomes than their white counterparts, the PRAMS questionnaire includes questions about racism, discrimination, and socioeconomic status.

Because the current survey and research protocol include questions about race, sexual orientation and gender identity, and class status, an overhaul is necessary to comply with the President’s executive order ending government diversity, equity, and inclusion (DEI) programs.

CDC employees who work on PRAMS have reported that the program will eventually continue without survey questions about race/ethnicity and other social determinants of health. However, the ability of a revised PRAMS questionnaire to support the program’s goal of finding groups of pregnant people and infants at heightened risk for adverse health outcomes is still unclear.

Furthermore, these revisions to the survey’s questions — some of which have been asked consistently since 1988 — will diminish the ability of program administrators, policymakers, and advocates to watch changes over time.

Currently, 26 Title X grantee agencies (all state health departments) take part in the PRAMS program, and both programs are often co-located in the same bureau or division. Even more family planning and sexual health service providers rely on PRAMS data for program planning.

Of note, PRAMS data is used to calculate unintended pregnancy and birth rates; access to and receipt of prepregnancy, prenatal, and postpartum care; patterns of health insurance coverage before, during, and after pregnancy; and performance measures on access to postpartum contraception.

Free Mental Health Resilience Webinar for Public Health Workers

Mental Health Mini-Talks:

Guiding Public Health Workplaces from Stress to Resilience

Free Thursday, March 13, 2025 | 3:00 – 4:30 PM PT

Join us for practical insights and strategies to foster a culture of well-being in public health by examining the root causes and impact of burnout, along with strategies for resilience, exploring psychological safety as a key to workplace well-being, and introducing the Leading for Wellness framework, which outlines leadership behaviors that support employee wellness and organizational success.

Continuing Education Information: 1.50 CECH for CHES

Register for the Stress to Resilience Training

The Looming Public Health System Crisis? Why Cutting Federal Funds Would Wreck Arizona’s Health System

Imagine waking up to a world where your local health department can’t track a measles outbreak, run immunization programs, or respond to foodborne illness outbreaks. That’s not a dystopian fantasy—it’s the reality Arizona could face if federal funds for public health are slashed.

That might not be a dream. It could eventually become a reality.

Shortly after Trump’s inauguration, his administration tried to cancel federal contracts and cooperative agreements with state and county health departments. A judge stepped in to block the move, but if that ruling is lifted—or if federal officials simply ignore it—it would be catastrophic for Arizona.

Why? Because more than 70% of county health department funding in Arizona comes from federal dollars.

Without it, the state would essentially have no functioning public health system. County health departments could still inspect restaurants (since that’s fee-based), but everything else—from infectious disease control to maternal health programs—would grind to a halt.

Infectious Disease Outbreaks: A Disaster Waiting to Happen

With no public health infrastructure, Arizona wouldn’t be able to track or respond to disease outbreaks like the recent measles cases in Texas and New Mexico. Surveillance for emerging threats like new COVID-19 variants? Gone. Efforts to contain tuberculosis? Over. Vector-borne diseases like West Nile virus and dengue? No one would be monitoring them.

Immunizations for Kids & Adults Would Collapse

Public health departments run vital immunization programs that protect children and adults from vaccine-preventable diseases. Slashing federal funds would mean fewer vaccines for low-income families, leading to outbreaks of diseases we thought were under control—like measles and whooping cough.

Foodborne & Vector-Borne Illnesses: Who’s Watching?

Public health officials investigate outbreaks of foodborne illnesses like salmonella and E. coli to keep the food supply safe. Without funding, those investigations stop, leaving the public (you) at risk. Similarly, Arizona’s fight against mosquito-borne diseases like West Nile virus would be gone, increasing the chances of widespread infections.

Maternal & Child Health Programs Would Disappear

Prenatal care programs, newborn screenings, and early childhood health initiatives rely heavily on federal funding. Without them, maternal and infant mortality rates could rise, reversing decades of progress.

No Emergency Preparedness for Pandemics, Heatwaves, or Bioterrorism

Public health emergencies—whether it’s a pandemic, extreme heat, or a bioterrorism threat—require coordinated responses. County health departments lead these efforts, ensuring Arizona can react quickly and effectively. If federal funds vanish, so does preparedness, putting millions at risk.

The Bottom Line

This isn’t an exaggeration—if these cuts happen, Arizona’s public health system would collapse. The consequences would be deadly. Public health funding isn’t just another budget line item—it’s what keeps our communities safe. Cutting it would be reckless and dangerous.

March 8 Legislative Update

This week was dominated by floor votes (called 3rd Read). Bills that successfully get approved on the floor vote then move over to the other chamber. Here’s a list of the public health related bills that have advanced out of their chamber this week:

Senate

SB1019 photo enforcement; traffic (AzPHA opposes)

SB1071 SNAP TANF verification (AzPHA Opposed)

SB1108 international medical licenses; provisional licensing (no Position)

SB1612 RFP document retention; AHCCCS (No Position)

SB1347 – no vote yet -comprehensive dental; ahcccs (AzPHA Supports)

SB1604 licensed secure health facility; defendants (AzPHA Supports)

SB1623 – no vote yet -GME appropriations (AzPHA Supports)

House

HB2001 behavioral health temporary licenses (AzPHA Supports)

HB2012 emergency use products; employers (AzPHA Opposed)

HB2130 claims; prior authorization (AzPHA Supports)

HB2058 immunization proof; higher education (AzPHA Opposed)

HB2063 parental notification; school immunizations (AzPHA Opposes)

HB2125 insurance coverage; hearing aids (AzPHA Supports)

HB2126 medical records; parental choice (AzPHA Opposes)

HB2145 registered sanitarians; qualifications (AzPHA Supports)

HB2164 school lunches; ultra processed food (AzPHA Supports)

HB2165 SNAP; prohibited purchases (AzPHA No Position)

HB2175 claims; prior auth; company conduct (AzPHA Supports)

HB2176 training; investigations; complaints (AzPHA Neutral)

HB2257 DCS, vaccination; child placement (AzPHA No Position)

HB2291 opioids, red cap packaging (AzPHA Supports)

HB2449 AHCCCS presumptive eligibility (AzPHA Opposed)

HB2894 Silver alert criteria (AzPHA Supports)